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KMID : 0861020020170010113
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Korea Journal of Herbology
2002 Volume.17 No. 1 p.113 ~ p.129
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Experimental Studies on the Hematopoietic Effects of the Pseudostellariae Radix
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徐榮培/Seo, Young-Bae
李龍求/李永喆/李太元/Lee, Yong-Koo/Lee, Young-Cheol/Lee, Tae-Won
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Abstract
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In order to investigate the hematopoietic effects of Pseudostellariae Radix various experiment about hematopoiesis were studied.
The results were obtained as follows:
1. In the proliferous effect of bone marrow cells, water extracts of Pseudostellariae Radix played an important role on the proliferating bone marrow cells compared with control group.
2. The water extracts of Pseudostellariae Radix activated the bone marrow cells.
3. The water extracts of Pseudostellariae Radix promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM.
4. In the bone marrow cells treated with CTX, the water extracts of Pseudostellariae Radix promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly.
According to the above results, water extracts of Pseudostellariae Radix promoted not only the differentiation of the bone marrow cells into CFU-GEMM which mother cell of erythrocytes, thrombocytes, monocytes and macrophages, but also the differentiation of the bone marrow cells into BFU-E. On the other hand, in the gene expression that have a lot of hematopoietic effects in the early differentiation of haematopoietic stem cells by promoting the gene expression of SCF, EPO, IL-4, IL-6 and so forth. Above results also demonstrates that the water extracts of Pseudostellariae Radix have somewhat meaningful effects in hematogenesis but not sufficient to explain its mechanisms about hematogenesis, therefore further deep studies should be accomplished about its mechanisms.
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